precipitated withdrawal syndrome
Acute withdrawal symptoms triggered by administration of an opioid antagonist to a person with opioid dependence.
Full Definition
Precipitated withdrawal syndrome occurs when an opioid antagonist (such as naloxone or naltrexone) is administered to someone with opioid dependence, rapidly displacing opioids from receptor sites and triggering immediate, intense withdrawal symptoms. Unlike natural withdrawal, which develops gradually as drug levels decline, precipitated withdrawal has rapid onset and can be particularly severe. This condition is a critical consideration in emergency medicine and when initiating certain medications like naltrexone, requiring careful timing and medical supervision.
Usage
Usage note: Use full term 'precipitated withdrawal syndrome' in formal documentation; distinguish from standard precipitated withdrawal
In Context
- "The emergency department noted precipitated withdrawal syndrome after naloxone administration to the overdose patient." — Medical record documentation
- "Patient education materials must warn about the risk of precipitated withdrawal syndrome when starting naltrexone therapy." — Treatment protocol guidelines