Professional
Technical
IVT
Kindling Effect
Progressive worsening of withdrawal symptoms with repeated episodes of cessation and relapse.
Full Definition
The kindling effect refers to the neurobiological phenomenon where repeated cycles of intoxication and withdrawal lead to increasingly severe withdrawal symptoms. This is particularly relevant in alcohol and benzodiazepine dependence, where each subsequent withdrawal episode becomes more dangerous and difficult to manage. The term originates from epilepsy research but has been adopted in addiction medicine to explain why patients with multiple prior detoxification attempts often require more intensive medical supervision.
Usage
Usage note: Capitalize only when beginning a sentence; often used with 'due to' or 'because of' constructions.
In Context
- "The patient's history of multiple failed detox attempts suggests kindling effect may complicate this withdrawal." — Medical assessment report
- "Due to kindling effect, the treatment team recommended inpatient rather than outpatient detoxification." — Treatment planning documentation
Also known as
withdrawal sensitization
neuroadaptation progression
Don't confuse with
tolerance
cross-tolerance