Intermediate
Technical
IVT
naloxone
Pronunciation: /nəˈlɒksən/
Opioid antagonist medication used to reverse opioid overdoses and prevent misuse of other opioids.
Full Definition
Naloxone is an opioid receptor antagonist that rapidly reverses the effects of opioid overdose by displacing opioids from brain receptors. Available as nasal spray (Narcan) or auto-injector (Evzio), it can be administered by non-medical personnel in emergency situations. In addiction medicine, naloxone is also combined with buprenorphine in formulations like Suboxone to deter intravenous misuse. The medication has no abuse potential and is considered safe for community distribution.
Usage
Usage note: Frequently confused with naltrexone; naloxone is for acute overdose reversal, naltrexone is for long-term maintenance.
In Context
- "Emergency responders administered naloxone to reverse the patient's opioid overdose." — emergency medical report
- "The harm reduction program distributed naloxone kits to family members of opioid users." — public health initiative
Also known as
Narcan
opioid reversal agent
opioid antagonist
Contrasted with
opioid agonist
Don't confuse with
naltrexone
buprenorphine