Professional
Technical
In the Industry Vocabulary Test
Peak and Trough Levels
Blood concentration measurements taken at maximum and minimum points in medication dosing cycles.
Full Definition
Peak and trough levels are laboratory measurements used to monitor medication concentrations in addiction treatment, particularly for methadone therapy. Peak levels are drawn 2-4 hours after dosing when drug concentration is highest, while trough levels are obtained just before the next dose when concentration is lowest. These measurements help clinicians optimize dosing, ensure therapeutic levels, identify medication diversion, and adjust for individual metabolic differences affecting drug clearance.
Usage
Usage note: Always use 'and' rather than ampersand; specify timing requirements in clinical contexts.
In Context
- "Peak and trough levels confirmed the patient was receiving adequate methadone despite continued withdrawal complaints." — Laboratory interpretation
- "The physician ordered peak and trough levels to investigate possible rapid metabolism of methadone." — Medical orders
Also known as
plasma levels
serum concentrations
Don't confuse with
steady state
therapeutic monitoring