Professional
Technical
IVT
Precipitated Withdrawal
Sudden onset of withdrawal symptoms triggered by administration of an antagonist medication.
Full Definition
Precipitated withdrawal occurs when an opioid antagonist (such as naloxone or naltrexone) is administered to someone with physical opioid dependence, rapidly displacing opioids from receptors and triggering immediate, severe withdrawal symptoms. This can be iatrogenic when occurring during medical treatment or intentionally induced as part of rapid detoxification protocols. The symptoms are typically more intense than naturally occurring withdrawal and require immediate medical management.
Usage
Usage note: Hyphenate when used as a compound adjective; emphasize medical supervision requirements.
In Context
- "The emergency physician was careful to avoid precipitated withdrawal when administering naloxone to the semi-conscious patient." — Emergency department note
- "Precipitated withdrawal symptoms required aggressive supportive care and comfort medications." — Medical progress note
Also known as
antagonist-induced withdrawal
Contrasted with
spontaneous withdrawal
gradual withdrawal
Don't confuse with
acute withdrawal
overdose reversal