vulnerable plaque
Atherosclerotic plaque with high-risk characteristics predisposing to rupture and acute coronary events.
Full Definition
Vulnerable plaque refers to coronary atherosclerotic lesions that have a high propensity for rupture, leading to acute coronary syndromes. These plaques typically have a large lipid core, thin fibrous cap, abundant inflammatory cells (particularly macrophages), and may show signs of intraplaque hemorrhage or neovascularization. Advanced imaging techniques such as intravascular ultrasound, optical coherence tomography, and near-infrared spectroscopy can help identify plaque vulnerability features that are not visible on conventional angiography.
Usage
Usage note: Distinguish from 'culprit lesion' which refers to the plaque that has already caused an acute event.
In Context
- "Optical coherence tomography identified vulnerable plaque characteristics including thin cap fibroatheroma." — Interventional cardiology report
- "The concept of vulnerable plaque has shifted focus from stenosis severity to plaque biology." — Cardiology review article