Lewy body
Pronunciation: LOO-ee body
Abnormal protein aggregates found in neurons, characteristic of Parkinson's disease and related disorders.
Full Definition
Lewy bodies are pathological protein inclusions composed primarily of misfolded alpha-synuclein found within neurons. These eosinophilic, intracytoplasmic structures are the hallmark pathological feature of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Lewy bodies disrupt normal cellular function and contribute to neurodegeneration. Their distribution pattern helps differentiate between parkinsonian syndromes. In clinical documentation, the presence of Lewy bodies can only be confirmed through post-mortem examination, though clinical features may suggest Lewy body pathology.
Usage
Usage note: Named after Friedrich Lewy; distinguish from other proteinaceous inclusions in neurodegenerative diseases.
In Context
- "Neuropathological examination revealed widespread cortical Lewy body pathology." — Autopsy neuropathology report
- "The clinical presentation was consistent with probable dementia with Lewy bodies." — Neurology consultation note