myasthenia gravis
Pronunciation: my-as-THEE-nee-ah GRAH-vis
Autoimmune neuromuscular disorder causing fluctuating weakness due to acetylcholine receptor antibodies.
Full Definition
Myasthenia gravis is an autoimmune disorder affecting the neuromuscular junction, where antibodies target acetylcholine receptors or related proteins. The hallmark feature is fluctuating muscle weakness that worsens with activity and improves with rest. Symptoms typically affect extraocular muscles, bulbar muscles, and limb muscles in a characteristic pattern. Diagnosis relies on clinical presentation, electrophysiological testing, and serological studies. The condition may be associated with thymic pathology and can present as isolated ocular symptoms or generalized weakness.
Usage
Usage note: Specify whether ocular or generalized form; include antibody status when available.
In Context
- "Acetylcholine receptor antibodies confirmed the diagnosis of myasthenia gravis." — Laboratory results interpretation
- "The patient's ptosis and diplopia improved markedly with pyridostigmine." — Follow-up neuromuscular clinic note