Intermediate
Technical
In the Industry Vocabulary Test
SSRI discontinuation syndrome
A cluster of symptoms that can occur when selective serotonin reuptake inhibitor medications are stopped abruptly or tapered too quickly.
Full Definition
SSRI discontinuation syndrome refers to a constellation of physical and psychological symptoms that may emerge when SSRI antidepressants are discontinued suddenly or reduced too rapidly. Symptoms can include dizziness, flu-like symptoms, sensory disturbances, and mood changes. The syndrome is more likely with shorter half-life SSRIs and emphasizes the importance of gradual medication tapering. Medical editors must distinguish this from relapse of underlying depression.
Usage
Usage note: Always specify which SSRI when documenting discontinuation syndrome, as risk varies by medication half-life.
In Context
- "The patient's dizziness and electric shock sensations were attributed to SSRI discontinuation syndrome following abrupt cessation of paroxetine." — Clinical case report
- "To prevent SSRI discontinuation syndrome, the medication taper schedule extended over six weeks." — Treatment plan documentation
Also known as
SSRI withdrawal syndrome
antidepressant discontinuation syndrome
Don't confuse with
medication relapse
serotonin syndrome