SAPPHIRE-HF
Also written as: SAPPHIRE-HF — Study to Assess the safety and PerformAnce of the exPansion of tHe Indication for caRdiac rEsynchronization therapy in Heart Failure
A clinical trial designation that editors frequently encounter in cardiac device imaging research papers and regulatory submissions.
Full Definition
SAPPHIRE-HF represents a specific clinical trial framework for cardiac resynchronization therapy studies. In editorial contexts, this acronym appears in research manuscripts, FDA submissions, and clinical guidelines where proper capitalization and hyphenation are critical. Editors must distinguish this from other cardiac trial acronyms and ensure consistent formatting throughout cardiovascular imaging publications. The term often appears in conjunction with technical imaging protocols and device efficacy endpoints.
Usage
Usage note: Always capitalize with hyphens. Do not italicize in running text.
In Context
- "The SAPPHIRE-HF trial protocol requires specific cardiac MRI sequences to evaluate left ventricular lead placement." — Clinical trial manuscript
- "Endpoints consistent with SAPPHIRE-HF guidelines were used to assess cardiac resynchronization therapy response." — Research publication