tissue plasminogen activator
Also written as: tPA — tissue plasminogen activator
Recombinant thrombolytic enzyme used to dissolve blood clots by converting plasminogen to plasmin in acute thrombotic conditions.
Full Definition
Tissue plasminogen activator (tPA) is a recombinant serine protease that serves as the primary thrombolytic agent for treating acute thrombotic conditions including stroke, myocardial infarction, and pulmonary embolism. This enzyme specifically converts plasminogen to plasmin, which breaks down fibrin clots. In angiology, tPA is used for catheter-directed thrombolysis, systemic thrombolysis, and pharmacomechanical interventions. Its fibrin-specific properties theoretically reduce systemic bleeding risk compared to non-specific agents, though hemorrhagic complications remain the primary limitation of thrombolytic therapy.
Usage
Usage note: Commonly abbreviated as tPA; distinguish from other thrombolytic agents.
In Context
- "Catheter-directed tissue plasminogen activator infusion was initiated for extensive deep vein thrombosis." — Interventional radiology procedure note
- "The patient received intravenous tissue plasminogen activator within the therapeutic window." — Emergency department treatment record