vulnerable plaque
Atherosclerotic lesion with high-risk morphological features predisposing to rupture and acute coronary events.
Full Definition
A vulnerable plaque is an atherosclerotic lesion characterized by specific morphological features that make it prone to rupture, leading to acute coronary syndromes. These plaques typically have a large lipid core, thin fibrous cap (less than 65 micrometers), increased macrophage infiltration, and reduced smooth muscle cell content. While vulnerable plaques may not cause significant luminal stenosis, their rupture can trigger thrombosis and acute vessel occlusion. Identification of vulnerable plaques is challenging and remains an active area of research in cardiovascular imaging.
Usage
Usage note: Term emphasizes rupture potential rather than current luminal compromise.
In Context
- "Intravascular imaging revealed characteristics consistent with a vulnerable plaque in the proximal LAD." — Cardiac catheterization report
- "The research focused on identifying vulnerable plaques before they cause acute coronary events." — Clinical research abstract