Endometrial Scratching
Deliberate injury to the endometrium performed to potentially improve implantation rates in subsequent embryo transfers.
Full Definition
Endometrial scratching, also known as endometrial injury, involves deliberately damaging the endometrial lining using a pipelle biopsy catheter or similar device. The procedure is typically performed in the luteal phase of the cycle preceding embryo transfer. The theoretical mechanism involves local inflammatory response and wound healing processes that may enhance endometrial receptivity and implantation. While some studies suggest improved pregnancy rates in women with repeated implantation failure, the evidence remains controversial and practice varies among clinics.
Usage
Usage note: Evidence for effectiveness is mixed; may be offered for repeated implantation failure cases.
In Context
- "Endometrial scratching was performed on cycle day 21 using a pipelle catheter prior to the frozen embryo transfer." — Procedure note
- "The efficacy of endometrial scratching in improving implantation rates remains a subject of ongoing research." — Clinical review article