Luteal Phase Defect
Also written as: LPD — Luteal Phase Defect
Inadequate progesterone production or shortened luteal phase that can impair implantation and early pregnancy maintenance.
Full Definition
Luteal phase defect refers to inadequate progesterone production by the corpus luteum, resulting in insufficient endometrial preparation for implantation or early pregnancy maintenance. It may manifest as a shortened luteal phase (less than 10 days), low progesterone levels, or abnormal endometrial histology. Causes include inadequate LH surge, poor follicular development, or corpus luteum dysfunction. In ART cycles, luteal phase support with progesterone supplementation is routinely provided to prevent this condition. Diagnosis can be challenging and may require multiple cycle assessments including progesterone levels and endometrial biopsy.
Usage
Usage note: Controversial diagnosis; luteal support is routine in ART regardless of suspected defect.
In Context
- "Recurrent pregnancy loss was attributed to luteal phase defect based on consistently low progesterone levels." — Reproductive endocrinology evaluation
- "Luteal phase defect was corrected with progesterone supplementation starting three days post-ovulation." — Treatment protocol