Intermediate
Technical
IVT
HER2-negative
Breast cancer cells that do not overexpress the HER2 protein, affecting treatment decisions.
Full Definition
HER2-negative refers to breast cancer tumors where the human epidermal growth factor receptor 2 (HER2) protein is not overexpressed or amplified. This classification is determined through immunohistochemistry or fluorescence in situ hybridization testing. HER2-negative tumors do not respond to HER2-targeted therapies like trastuzumab. The designation is critical for treatment planning and is typically combined with hormone receptor status to determine molecular subtype.
Usage
Usage note: Always hyphenate when used as an adjective. Use HER2- symbol in clinical shorthand.
In Context
- "The pathology report confirmed HER2-negative status, ruling out targeted anti-HER2 therapy." — pathology report
- "HER2-negative, hormone receptor-positive tumors typically receive endocrine therapy." — treatment protocol
Also known as
HER2-
Contrasted with
HER2-positive
HER2+
Don't confuse with
HER2-positive