Advanced
Technical
IVT
luminal B
A molecular subtype of breast cancer characterized by hormone receptor positivity with higher proliferation rates.
Full Definition
Luminal B is one of the intrinsic molecular subtypes of breast cancer, defined by estrogen receptor and/or progesterone receptor positivity combined with higher proliferation indices (typically Ki-67 >20%) or HER2 overexpression. These tumors generally have a more aggressive behavior than luminal A tumors and may require chemotherapy in addition to endocrine therapy. The subtype classification guides treatment decisions and prognostic assessments. Luminal B tumors can be further subdivided into HER2-positive and HER2-negative variants.
Usage
Usage note: Capitalize 'B' when referring to the specific molecular subtype.
In Context
- "The molecular profiling revealed luminal B subtype, indicating need for chemotherapy consideration." — molecular diagnostics report
- "Luminal B tumors have intermediate prognosis between luminal A and triple-negative subtypes." — research publication
Contrasted with
luminal A
Don't confuse with
luminal A