lymphatic invasion
The presence of cancer cells within lymphatic vessels, indicating potential for spread to lymph nodes.
Full Definition
Lymphatic invasion, also known as lymphovascular invasion when combined with vascular invasion, refers to the presence of cancer cells within lymphatic vessels as seen on histologic examination. This finding suggests that cancer cells have the potential to spread through the lymphatic system to regional lymph nodes and beyond. Lymphatic invasion is considered an adverse prognostic factor and may influence staging, treatment decisions, and follow-up protocols. It is routinely reported in pathology specimens and contributes to overall risk assessment.
Usage
Usage note: Distinguish from vascular invasion, though often reported together as lymphovascular invasion.
In Context
- "Extensive lymphatic invasion was identified in multiple areas of the tumor specimen." — Pathology report
- "The presence of lymphatic invasion upgraded the patient's risk category for adjuvant therapy consideration." — Multidisciplinary team note