apligraf
Pronunciation: AP-li-graf
A bilayered living skin substitute composed of human dermal fibroblasts and keratinocytes used for burn wound coverage.
Full Definition
Apligraf is a commercially available bilayered living skin substitute that contains both human dermal fibroblasts in a bovine collagen matrix and human keratinocytes. It is used as a temporary biological dressing for partial-thickness burns and as an adjunct to autografting in full-thickness burns. The product provides both dermal and epidermal components, making it particularly valuable when donor sites are limited. Unlike synthetic alternatives, Apligraf contains living cells that can integrate with the wound bed and promote healing through growth factor production.
Usage
Usage note: Capitalize as a proprietary product name; avoid confusing with other skin substitutes that lack living cellular components.
In Context
- "The burn surgeon opted for Apligraf application to the 15% TBSA partial-thickness burns on the patient's torso." — surgical procedure note
- "Apligraf demonstrated superior take rates compared to traditional xenograft dressings in the pediatric burn population." — clinical research paper