Advanced
Technical
IVT
chromosomal instability
Increased rate of chromosome structure or number alterations during cell division.
Full Definition
Chromosomal instability (CIN) refers to an elevated rate of chromosome structure alterations or numerical chromosome changes during cell division. This genomic instability manifests as aneuploidy, chromosome rearrangements, deletions, amplifications, and translocations. CIN is observed in approximately 85% of solid tumors and contributes to cancer development by causing loss of tumor suppressor genes or activation of oncogenes. It can result from defects in chromosome segregation machinery, DNA damage checkpoints, or repair mechanisms.
Usage
Usage note: Commonly abbreviated as CIN; distinguish from MSI (microsatellite instability).
In Context
- "High levels of chromosomal instability characterized the tumor sample." — Genomic analysis report
- "Chromosomal instability contributed to therapeutic resistance development." — Research publication
Also known as
CIN
genomic instability
Contrasted with
chromosomal stability
genomic stability
Don't confuse with
microsatellite instability
genetic instability