Professional
Technical
IVT
hyperprogression
Accelerated tumor growth following immunotherapy initiation, exceeding the natural progression rate.
Full Definition
Hyperprogression is a phenomenon observed in some cancer patients where tumor growth accelerates significantly after starting immunotherapy, particularly immune checkpoint inhibitors. This occurs in approximately 4-29% of patients and represents growth that exceeds the tumor's natural progression rate. The mechanism is not fully understood but may involve immune system activation that paradoxically promotes tumor growth. Recognition is crucial for editors reviewing clinical trial data and treatment protocols.
Usage
Usage note: Distinguish from pseudoprogression, which involves apparent growth followed by shrinkage.
In Context
- "The patient experienced hyperprogression within 6 weeks of pembrolizumab initiation." — Clinical case report
- "Hyperprogression rates varied significantly across tumor types in the meta-analysis." — Research manuscript
Also known as
accelerated progression
immune-mediated acceleration
Contrasted with
tumor regression
disease stabilization
Don't confuse with
pseudoprogression
disease progression