immune-related adverse event
Also written as: irAE — Immune-Related Adverse Event
Side effects from immunotherapy caused by excessive immune activation against normal tissues.
Full Definition
Immune-related adverse events (irAEs) are side effects of immune checkpoint inhibitor therapy resulting from enhanced immune activity against normal, healthy tissues. These events can affect any organ system but commonly involve the skin, gastrointestinal tract, liver, lungs, and endocrine glands. irAEs typically follow different patterns from conventional chemotherapy toxicities, may occur weeks to months after treatment initiation, and often require immunosuppressive therapy for management while balancing the need to maintain antitumor immunity.
Usage
Usage note: Hyphenate as immune-related adverse event; commonly abbreviated as irAE.
In Context
- "The patient developed grade 3 immune-related adverse events affecting the liver and required high-dose corticosteroids." — Toxicity management protocol
- "Early recognition and management of irAEs is crucial for optimal immunotherapy outcomes." — Clinical practice guideline