Metronomic Chemotherapy
Pronunciation: meh-truh-NOM-ik
A treatment approach using continuous, low-dose chemotherapy without extended drug-free intervals to target tumor vasculature and immune system.
Full Definition
Metronomic chemotherapy refers to the frequent, regular administration of chemotherapeutic drugs at doses significantly below the maximum tolerated dose, with no prolonged drug-free breaks. This approach differs from conventional maximum tolerated dose chemotherapy by targeting the tumor microenvironment, particularly tumor-associated endothelial cells and immune suppressor cells, rather than focusing primarily on direct tumor cell killing. The strategy aims to inhibit angiogenesis, activate anti-tumor immunity, and minimize drug resistance development while reducing toxicity. This term frequently appears in research protocols, treatment guidelines for refractory cancers, and discussions of alternative dosing strategies.
Usage
Usage note: Distinguish from 'maintenance therapy' which typically follows induction treatment; metronomic refers specifically to the dosing schedule and mechanism.
In Context
- "The investigational arm employed metronomic chemotherapy with daily oral cyclophosphamide to minimize treatment-related toxicity." — Research paper
- "Metronomic chemotherapy protocols showed promise in pediatric patients who had exhausted conventional treatment options." — Clinical review