Radiation Recall
Inflammatory reaction in previously irradiated tissue triggered by subsequent chemotherapy or other systemic agents.
Full Definition
An acute inflammatory response that occurs in tissue previously exposed to radiation therapy when certain chemotherapeutic agents or other drugs are administered weeks to years after radiation treatment. The reaction manifests as erythema, desquamation, and sometimes ulceration confined precisely to the previously irradiated field. Common triggering agents include anthracyclines, taxanes, gemcitabine, and targeted therapies. The phenomenon can occur in skin, lungs, esophagus, or other organs that received prior radiation. Recognition of radiation recall is important for clinical decision-making and patient safety, as it may require treatment modification or discontinuation.
Usage
Usage note: May be written as 'radiation recall reaction' or 'radiation recall phenomenon' for clarity.
In Context
- "The patient developed severe radiation recall after initiation of doxorubicin therapy." — Adverse event report
- "Radiation recall was observed in the previously treated breast tissue following gemcitabine administration." — Clinical case description