tumor burden
The total amount of cancer in a patient's body, often measured by tumor size, number of lesions, or biomarker levels.
Full Definition
Tumor burden represents the total volume or mass of malignant tissue present in a patient, encompassing primary tumors and all metastatic sites. This measurement can be quantified through various methods including imaging-based assessments (sum of target lesion diameters), functional imaging metrics, circulating tumor markers, or molecular indicators such as circulating tumor DNA. Tumor burden serves as an important prognostic factor and treatment response indicator, with higher burden generally associated with worse outcomes and requiring more intensive therapeutic approaches.
Usage
Usage note: Can be measured by various methods; specify measurement approach when relevant (imaging-based, biomarker-based, etc.).
In Context
- "The patient's high tumor burden precluded surgical intervention, necessitating systemic therapy." — Multidisciplinary team discussion
- "Serial imaging demonstrated significant reduction in tumor burden following immunotherapy." — Response assessment