tumor microenvironment
Also written as: TME — tumor microenvironment
The cellular environment surrounding a tumor, including immune cells, blood vessels, and supporting tissues.
Full Definition
The tumor microenvironment (TME) encompasses the complex ecosystem of cells, molecules, and structures that surround and interact with cancer cells within a tumor. This includes immune cells (T cells, macrophages, dendritic cells), stromal cells (fibroblasts, endothelial cells), extracellular matrix, blood vessels, and signaling molecules. The TME plays a critical role in cancer progression, metastasis, and treatment response. Understanding the TME has become crucial for developing immunotherapies and other targeted treatments, as it can either promote or inhibit cancer growth depending on its composition and activation state.
Usage
Usage note: Can be abbreviated as TME after first use. Do not confuse with tumor stroma, which is a component of the TME.
In Context
- "Analysis of the tumor microenvironment revealed high levels of immunosuppressive cytokines." — Pathology report
- "The drug's efficacy depends on its ability to modulate the TME." — Drug development summary