Intermediate
Technical
IVT
chromosomal microarray
Genomic analysis technique that detects copy number variations and chromosomal imbalances across the genome.
Full Definition
A laboratory method that uses DNA hybridization to microarray chips containing thousands of genomic probes to detect copy number gains and losses throughout the genome. Chromosomal microarray analysis (CMA) can identify deletions, duplications, and regions of loss of heterozygosity that may be missed by conventional karyotyping. In cancer genomics, this technique helps identify chromosomal instability patterns and copy number alterations that contribute to oncogenesis or influence treatment selection.
Usage
Usage note: CMA abbreviation acceptable; distinguish from gene expression microarrays which measure RNA levels.
In Context
- "Chromosomal microarray revealed multiple copy number alterations consistent with chromosomal instability in the ovarian cancer specimen." — Genomic testing report
- "The laboratory uses chromosomal microarray to detect large-scale genomic rearrangements missed by sequencing approaches." — Technical method description
Also known as
CMA
array comparative genomic hybridization
aCGH
Contrasted with
single nucleotide analysis
point mutation testing
Don't confuse with
karyotype analysis
fluorescence in situ hybridization