CIViC
Pronunciation: SIV-ik
Also written as: CIViC — Clinical Interpretation of Variants in Cancer
Clinical Interpretation of Variants in Cancer database providing crowdsourced curation of cancer variant clinical relevance.
Full Definition
CIViC (Clinical Interpretation of Variants in Cancer) is an open-access database that provides expert-crowdsourced curation of the clinical relevance of cancer variants. The platform allows researchers and clinicians to contribute and review evidence for variant-drug associations, prognostic implications, and diagnostic applications. CIViC uses a structured evidence model with detailed provenance tracking and expert review processes. Editors working with cancer genomics literature must understand CIViC's evidence hierarchy and ensure proper attribution when referencing CIViC evidence items in clinical reports and research publications.
Usage
Usage note: Capitalize as CIViC, not CIVIC or Civic. Include evidence item identifiers (EID) when referencing specific evidence.
In Context
- "The therapeutic evidence for this mutation was supported by CIViC evidence item EID789." — clinical genomics report
- "CIViC curation indicates this variant has predictive significance for immunotherapy response." — molecular pathology summary