Intermediate
Technical
IVT
fusion transcript
An abnormal RNA molecule created when two normally separate genes are joined due to chromosomal rearrangement.
Full Definition
A chimeric RNA product resulting from chromosomal translocations, inversions, or deletions that bring together coding sequences from two distinct genes. Fusion transcripts often create oncogenic proteins with altered function, such as constitutively active kinases or aberrant transcription factors. Detection of specific fusion transcripts guides targeted therapy selection and serves as diagnostic biomarkers in various cancer types, particularly sarcomas and hematologic malignancies.
Usage
Usage note: Use consistent notation for fusion partners (e.g., EML4-ALK vs ALK-EML4 based on chromosomal position).
In Context
- "RNA sequencing identified an EML4-ALK fusion transcript in 5% of lung adenocarcinoma cases." — Biomarker discovery study
- "The patient's BCR-ABL1 fusion transcript levels decreased by 3-log following imatinib treatment." — Treatment monitoring report
Also known as
gene fusion
chimeric transcript
fusion gene
Don't confuse with
splice variant
isoform