HRD
Pronunciation: H-R-D
Also written as: HRD — Homologous Recombination Deficiency
Homologous Recombination Deficiency, a genomic instability pattern predictive of PARP inhibitor response.
Full Definition
HRD (Homologous Recombination Deficiency) represents impaired ability to repair double-strand DNA breaks through homologous recombination, often resulting from BRCA1/2 mutations or other pathway alterations. HRD tumors exhibit characteristic genomic scarring patterns including loss of heterozygosity, telomeric allelic imbalance, and large-scale state transitions. HRD scoring algorithms combine these signatures to predict sensitivity to PARP inhibitors and platinum chemotherapy. Editors must understand that HRD can result from various mechanisms beyond BRCA mutations and that HRD scores may vary between different commercial assays and scoring methodologies.
Usage
Usage note: Capitalize as HRD. Include specific HRD score when available and specify the scoring algorithm used.
In Context
- "The HRD score of 42 indicated significant genomic instability and potential PARP inhibitor sensitivity." — precision oncology report
- "HRD-positive ovarian cancers demonstrated superior response rates to olaparib maintenance therapy." — clinical trial results