Intermediate
Technical
In the Industry Vocabulary Test
microsatellite stable
Cancer classification indicating normal DNA mismatch repair function and intact microsatellite sequences.
Full Definition
A molecular classification describing tumors with functional DNA mismatch repair systems and stable microsatellite sequences. Microsatellite stable (MSS) tumors contrast with microsatellite instability-high (MSI-H) cancers and typically show different treatment responses, particularly to immunotherapy. MSS status is determined through molecular testing and has important implications for treatment selection in colorectal and other cancers.
Usage
Usage note: Always capitalize MSS abbreviation; distinguish from microsatellite instability in clinical contexts.
In Context
- "The colorectal adenocarcinoma was classified as microsatellite stable, indicating intact mismatch repair function." — Pathology report
- "Microsatellite stable tumors typically show limited response to checkpoint inhibitor therapy." — Treatment recommendation
Also known as
MSS
Contrasted with
microsatellite instability-high
MSI-H
Don't confuse with
mismatch repair proficient
microsatellite instability