tumor evolution trajectory
The temporal sequence of genomic changes that occur during cancer development, progression, and treatment response.
Full Definition
Tumor evolution trajectory describes the dynamic genomic landscape changes that occur throughout a cancer's natural history, from initial transformation through metastasis and treatment resistance. This concept encompasses both the temporal ordering of mutation acquisition and the selective pressures that drive clonal expansion or contraction. Understanding evolution trajectories is crucial for predicting treatment responses, anticipating resistance mechanisms, and designing sequential therapy strategies. Advanced genomic technologies now enable reconstruction of these trajectories through phylogenetic analysis of multiple tumor samples or longitudinal liquid biopsy monitoring.
Usage
Usage note: Focus on the temporal and directional aspects of genomic change over time.
In Context
- "The tumor evolution trajectory revealed early acquisition of TP53 mutations followed by late emergence of drug resistance alterations." — Evolutionary genomics study
- "Longitudinal sampling allowed reconstruction of the complete tumor evolution trajectory from diagnosis through multiple treatment lines." — Research methodology