tumor-informed monitoring
Personalized surveillance strategy using patient-specific tumor genomic alterations to detect circulating tumor DNA and monitor disease status.
Full Definition
Tumor-informed monitoring represents an advanced approach to cancer surveillance that leverages the unique genomic signature of an individual patient's tumor to create personalized monitoring assays. This methodology first characterizes the primary tumor's genetic alterations through comprehensive sequencing, then designs patient-specific assays to detect these exact mutations in circulating tumor DNA from blood samples. The approach enables highly sensitive detection of minimal residual disease, early recurrence detection, and real-time monitoring of treatment response with superior specificity compared to generic circulating biomarkers.
Usage
Usage note: Emphasize the personalized aspect that distinguishes this from standard liquid biopsy approaches.
In Context
- "Tumor-informed monitoring detected molecular recurrence six months before radiographic evidence of disease progression." — Clinical trial report
- "The tumor-informed monitoring assay was designed based on the patient's unique KRAS G12D and TP53 R175H mutations." — Laboratory protocol