adenoma-carcinoma sequence

Full Definition

The adenoma-carcinoma sequence describes the stepwise progression from normal colonic epithelium through increasingly dysplastic adenomatous polyps to invasive colorectal carcinoma. This well-established pathway typically occurs over 10-15 years, providing the biological rationale for colorectal cancer screening through detection and removal of precancerous adenomas. Understanding this sequence is fundamental to interpreting colonoscopic findings and determining appropriate surveillance intervals.

In Context

• "The adenoma-carcinoma sequence provides the biological foundation for colorectal cancer screening programs." — Educational material
• "Genetic analysis revealed mutations consistent with the classical adenoma-carcinoma sequence." — Pathology report