ASC-H
Also written as: ASC-H — Atypical Squamous Cells - Cannot exclude High-grade lesion
Cytological finding of uncertain significance that cannot rule out the presence of a high-grade precancerous lesion.
Full Definition
Atypical Squamous Cells - Cannot exclude High-grade lesion represents cellular changes that are more concerning than typical ASC-US but fall short of a definitive HSIL diagnosis. ASC-H findings carry a significant risk of underlying high-grade disease and warrant immediate colposcopic evaluation. This category bridges the gap between clearly benign changes and definitive high-grade lesions, requiring careful clinical management to avoid missing significant disease.
Usage
Usage note: Include hyphens in abbreviation; spell out full form on first use in clinical protocols.
In Context
- "ASC-H results mandate colposcopy referral due to the elevated risk of underlying HSIL or worse." — Laboratory reporting guideline
- "The distinction between ASC-H and HSIL can be challenging and may require expert cytopathology review." — Quality assurance training material