heparinization
The administration of heparin to achieve systemic anticoagulation before cardiopulmonary bypass.
Full Definition
Heparinization is the process of administering heparin, an anticoagulant medication, to prevent blood clotting during cardiopulmonary bypass. Before initiating bypass, patients receive a loading dose of heparin (typically 300-400 units/kg) to achieve an activated clotting time (ACT) greater than 400-500 seconds. Adequate heparinization is essential to prevent thrombosis within the bypass circuit. The effectiveness is monitored through serial ACT measurements, and additional heparin doses are given as needed to maintain therapeutic anticoagulation throughout the procedure.
Usage
Usage note: Often described as 'full' or 'systemic' heparinization in cardiac surgery.
In Context
- "Full heparinization was achieved with an ACT of 480 seconds before bypass initiation." — anesthesia record
- "Additional heparin was required to maintain adequate heparinization during the procedure." — perfusion note