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systemic inflammatory response syndrome
Widespread inflammatory reaction triggered by cardiopulmonary bypass, characterized by cytokine release and organ dysfunction.
Full Definition
A complex inflammatory cascade initiated by exposure of blood to the artificial surfaces of the bypass circuit, surgical trauma, and ischemia-reperfusion injury. SIRS manifests as fever, leukocytosis, increased vascular permeability, and potential organ dysfunction. The severity correlates with bypass duration and patient factors. Management includes anti-inflammatory strategies, biocompatible circuits, and techniques to minimize bypass time and foreign surface exposure.
Usage
Usage note: Commonly abbreviated as SIRS; specific to cardiac surgery context.
In Context
- "The patient developed SIRS after prolonged cardiopulmonary bypass, requiring steroid therapy." — ICU progress note
- "Heparin-coated circuits may reduce systemic inflammatory response syndrome severity." — Clinical protocol
Also known as
SIRS
bypass inflammatory response
Don't confuse with
sepsis
multiple organ dysfunction