vasoplegia
A condition of severe vasodilation and hypotension despite adequate intravascular volume and cardiac output.
Full Definition
Vasoplegia is a pathophysiologic condition characterized by severe vasodilation, hypotension, and decreased systemic vascular resistance despite adequate or increased cardiac output and normal intravascular volume. In cardiac surgery, vasoplegia commonly occurs after cardiopulmonary bypass due to inflammatory responses, complement activation, and endothelial dysfunction. The condition typically manifests as warm, vasodilated extremities with low diastolic pressures and wide pulse pressures. Treatment involves vasopressor therapy, often with agents like norepinephrine or vasopressin, to restore vascular tone and adequate perfusion pressure.
Usage
Usage note: Often described as post-bypass or post-cardiopulmonary bypass vasoplegia.
In Context
- "The patient developed vasoplegia requiring high-dose norepinephrine support." — postoperative note
- "Methylene blue was considered for refractory vasoplegia unresponsive to conventional vasopressors." — ICU consultation