MOLLI sequence
Pronunciation: MOL-ee
Modified Look-Locker inversion recovery MRI sequence used for rapid T1 mapping of the myocardium.
Full Definition
Modified Look-Locker Inversion recovery (MOLLI) is a widely used cardiac MRI pulse sequence designed for fast and accurate T1 mapping of the heart. The technique acquires multiple images at different inversion times following an inversion pulse, allowing for calculation of T1 relaxation times on a pixel-by-pixel basis. MOLLI sequences can be completed within a single breath-hold, making them practical for clinical use. The resulting T1 maps are used to assess myocardial fibrosis, edema, and infiltrative diseases. Common MOLLI schemes include 5(3)3 and 4(1)3(1)2 patterns, where numbers indicate images acquired and parentheses show recovery periods.
Usage
Usage note: Include the specific MOLLI scheme (e.g., 5(3)3) when describing protocols.
In Context
- "A 5(3)3 MOLLI sequence was used to generate native T1 maps in short-axis orientation." — MRI protocol description
- "The MOLLI-derived T1 values were significantly elevated compared to normal reference ranges." — Research study report