in-stent restenosis
Also written as: ISR — In-Stent Restenosis
Re-narrowing of coronary artery lumen within a previously implanted stent due to neointimal hyperplasia.
Full Definition
In-stent restenosis refers to the re-narrowing of a coronary artery within the boundaries of a previously implanted stent, typically defined as greater than 50% luminal narrowing. This process is driven primarily by neointimal hyperplasia, where smooth muscle cells proliferate and migrate into the vessel lumen. The condition usually manifests as recurrent angina months after the initial procedure and may require repeat intervention with balloon angioplasty, drug-eluting stent implantation, or surgical bypass depending on the extent and complexity.
Usage
Usage note: Always hyphenate. ISR is the standard abbreviation. Distinguish from edge restenosis, which occurs adjacent to stent edges.
In Context
- "Angiography revealed severe in-stent restenosis with 80% luminal narrowing." — Repeat catheterisation report
- "The patient's recurrent symptoms were attributed to in-stent restenosis of the previously treated LAD." — Cardiology clinic note