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Intermediate Technical In the Industry Vocabulary Test

MACE

Pronunciation: MACE (rhymes with face)

Also written as: MACE — Major Adverse Cardiovascular Events

Major adverse cardiovascular events, a composite endpoint used in clinical trials and outcome studies.

Full Definition

MACE (Major Adverse Cardiovascular Events) represents a composite clinical endpoint commonly used in cardiovascular research and clinical practice to assess patient outcomes. The definition may vary between studies but typically includes cardiovascular death, myocardial infarction, and stroke. Some definitions also include revascularization procedures. MACE serves as a standardized measure for comparing treatment efficacy and safety across different therapeutic interventions in cardiovascular medicine.

Usage

Usage note: Always define MACE components when first used in clinical documentation.

In Context

  • "The primary endpoint was MACE at 12 months, defined as death, MI, or stroke." — Clinical trial protocol
  • "MACE rates were significantly lower in the drug-eluting stent group compared to bare metal stents." — Research study results

Also known as

major adverse cardiac events composite cardiovascular endpoint

Don't confuse with

MACE-like events secondary endpoints
left main coronary artery disease ← Back to glossary mechanical circulatory support

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