Brugada syndrome
Pronunciation: brew-GAH-da
An inherited cardiac arrhythmia disorder characterized by abnormal electrocardiogram findings and increased risk of sudden cardiac death.
Full Definition
Brugada syndrome is a genetic channelopathy affecting cardiac sodium channels, leading to distinctive ECG patterns and predisposing patients to ventricular arrhythmias. The condition is diagnosed through characteristic ST-segment elevation in leads V1-V3, often requiring provocative testing with sodium channel blockers. It predominantly affects young males and is a leading cause of sudden cardiac death in structurally normal hearts. Management typically involves implantable cardioverter-defibrillator placement in high-risk patients.
Usage
Usage note: Named after the Brugada brothers who first described the syndrome. Capitalize when referring to the specific syndrome.
In Context
- "The patient's ECG showed a Type 1 Brugada pattern with coved ST-elevation in V1-V2." — Cardiology consultation note
- "Family screening revealed two siblings with concealed Brugada syndrome requiring ajmaline provocation testing." — Genetic cardiology report