reperfusion injury
Tissue damage that occurs when blood supply returns to tissue after ischemia, paradoxically worsening injury.
Full Definition
Reperfusion injury refers to the tissue damage that occurs when blood flow is restored to previously ischemic myocardium. Although reperfusion is essential to salvage ischemic tissue, the sudden return of oxygen and nutrients can paradoxically cause additional cellular damage through mechanisms including oxidative stress, calcium overload, and inflammatory responses. This phenomenon explains why some patients may experience worsening cardiac function or arrhythmias immediately after successful revascularization. Understanding reperfusion injury has led to strategies for myocardial protection during interventional procedures.
Usage
Usage note: Hyphenate when used as a compound modifier.
In Context
- "Despite successful thrombolysis, the patient developed reperfusion injury with ventricular arrhythmias." — Case report
- "Pharmacological preconditioning may help reduce reperfusion injury during primary PCI." — Research paper