ADVANCE study
Also written as: ADVANCE — Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation
Clinical trial investigating intensive glucose control and blood pressure management in type 2 diabetes.
Full Definition
The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) study was a factorial randomized controlled trial that examined both intensive glucose control and blood pressure reduction in patients with type 2 diabetes. Unlike ACCORD, ADVANCE showed cardiovascular benefits with intensive glucose control, particularly in reducing nephropathy progression, contributing to nuanced diabetes management recommendations.
Usage
Usage note: Distinguish from ACCORD study which had different outcomes for intensive glucose control.
In Context
- "ADVANCE study results supported moderate intensive glycemic control in younger diabetic patients." — systematic review
- "The ADVANCE trial demonstrated renal benefits of glucose lowering independent of blood pressure effects." — nephrology journal