DCCT
Also written as: DCCT — Diabetes Control and Complications Trial
Landmark trial demonstrating that intensive glucose control reduces diabetic complications in type 1 diabetes.
Full Definition
The Diabetes Control and Complications Trial (DCCT) was a pivotal randomized controlled trial conducted from 1983-1993 that definitively proved intensive glycemic control significantly reduces the risk of diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) in patients with type 1 diabetes. The study compared conventional insulin therapy to intensive insulin therapy and established the fundamental principle that glucose control prevents diabetic complications, revolutionizing diabetes care standards.
Usage
Usage note: Often referenced alongside EDIC, its observational follow-up study.
In Context
- "The DCCT established the glucose hypothesis as the foundation of diabetes care." — endocrinology textbook
- "DCCT findings were extended by the EDIC follow-up study showing legacy effects." — clinical practice guideline