MACE
Also written as: MACE — Major Adverse Cardiovascular Events
Major adverse cardiovascular events, a composite endpoint used in clinical trials.
Full Definition
Major Adverse Cardiovascular Events (MACE) is a standardized composite endpoint used in cardiovascular outcome trials, typically including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. This endpoint allows researchers to assess the overall cardiovascular benefit or risk of therapeutic interventions in a statistically powered manner. MACE endpoints may be expanded to include additional events such as hospitalization for heart failure or urgent revascularization procedures, depending on the specific study design and therapeutic area.
Usage
Usage note: Use all capitals when abbreviated; define on first use in documents.
In Context
- "The primary endpoint of MACE was reduced by 14% in the treatment group compared to placebo." — Clinical trial report
- "Three-point MACE includes cardiovascular death, myocardial infarction, and stroke." — Study protocol