pannus
Pronunciation: PAN-us
Fibrous tissue overgrowth that can obstruct prosthetic heart valves or interfere with cardiac function.
Full Definition
Pannus formation refers to the development of fibrous, inflammatory tissue that grows over or around prosthetic heart valves, potentially causing obstruction or regurgitation. This tissue consists of fibroblasts, macrophages, and extracellular matrix that can progressively thicken and calcify over time. Pannus formation is more commonly associated with mechanical prosthetic valves and can lead to valve dysfunction requiring reoperation. The process is influenced by factors such as valve position, patient age, and inflammatory response. Echocardiographic monitoring is essential for early detection, as pannus can mimic valve thrombosis but requires different treatment approaches.
Usage
Usage note: Distinguish from thrombosis in prosthetic valve dysfunction discussions.
In Context
- "Echocardiography revealed significant pannus formation causing mitral valve obstruction five years after replacement." — Cardiology consultation note