Intermediate
Technical
IVT
dobutamine
A synthetic catecholamine inotrope that increases cardiac contractility and heart rate by stimulating beta-1 adrenergic receptors.
Full Definition
Dobutamine is a beta-1 selective adrenergic agonist commonly used in cardiovascular anesthesia to improve myocardial contractility and cardiac output. It has minimal effects on heart rate and systemic vascular resistance compared to other catecholamines. The drug is particularly useful during cardiac surgery for managing low cardiac output states and facilitating weaning from cardiopulmonary bypass. Dosing typically ranges from 2.5 to 20 mcg/kg/min with careful monitoring of hemodynamics.
Usage
Usage note: Distinguish from dopamine, which has additional dopaminergic and alpha effects at higher doses.
In Context
- "The anesthesiologist initiated a dobutamine infusion at 5 mcg/kg/min to improve contractility post-bypass." — Operative report
- "Weaning from cardiopulmonary bypass was facilitated with dobutamine support." — Anesthesia record
Also known as
dobutrex
Contrasted with
negative inotrope
Don't confuse with
dopamine
epinephrine