reoxygenation injury
Cellular damage that occurs when oxygen supply is restored after a period of ischemia.
Full Definition
Reoxygenation injury, also known as reperfusion injury, refers to the paradoxical tissue damage that occurs when blood supply and oxygen delivery are restored to previously ischemic tissue. During cardiac surgery, this phenomenon is particularly relevant when the aortic cross-clamp is removed and coronary perfusion resumes. The injury results from the generation of reactive oxygen species, calcium overload, and inflammatory responses. Strategies to minimize reoxygenation injury include controlled reperfusion, antioxidant administration, and gradual restoration of normal physiologic conditions.
Usage
Usage note: Often used interchangeably with 'reperfusion injury' in cardiac surgery contexts.
In Context
- "Controlled reperfusion was employed to minimize reoxygenation injury to the myocardium." — Surgical technique description
- "Elevated troponin levels suggested some degree of reoxygenation injury despite protective measures." — Post-operative assessment