MACE
Also written as: MACE — Major Adverse Cardiovascular Events
Major Adverse Cardiovascular Events, a composite endpoint used in clinical trials to measure serious cardiac outcomes.
Full Definition
Major Adverse Cardiovascular Events (MACE) is a standardized composite endpoint commonly used in cardiovascular clinical trials and research studies. The definition typically includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, though some studies may also include urgent revascularization procedures or hospitalization for unstable angina. MACE serves as a primary endpoint because it captures the most clinically significant adverse outcomes and provides sufficient statistical power for trial design.
Usage
Usage note: Always define the specific components of MACE when first mentioned in clinical documentation, as definitions vary between studies.
In Context
- "The primary endpoint was MACE at 12 months, occurring in 8.2% of the intervention group." — Clinical trial publication
- "Patients in the high-risk category showed a threefold increase in MACE compared to controls." — Research abstract