no-reflow phenomenon
Pronunciation: noh-REE-floh fuh-NOM-uh-non
Failure to restore adequate coronary blood flow despite successful opening of an occluded coronary artery during intervention.
Full Definition
The no-reflow phenomenon occurs when mechanical restoration of coronary artery patency fails to achieve adequate myocardial perfusion at the tissue level. This complication can occur during percutaneous coronary intervention, particularly in patients with acute myocardial infarction, and is attributed to microvascular dysfunction, embolization of thrombotic material, or inflammation. No-reflow is associated with worse clinical outcomes, larger infarct size, and reduced left ventricular recovery. Treatment may include vasodilators, anti-platelet agents, or mechanical thrombectomy devices.
Usage
Usage note: Hyphenate 'no-reflow' when used as a compound modifier.
In Context
- "Despite successful stent deployment, the patient developed no-reflow phenomenon requiring vasodilator therapy." — Interventional cardiology complication report
- "The no-reflow phenomenon was treated with intracoronary adenosine and mechanical thrombectomy." — Procedure technical description